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...a ‘physiological’ cell system. Specifically we will use different cell lines to compare brain regions: oligodendrocyte-like, neuronal or astrocyte. We aim to compare the presence of these autoantibodies in ADEM...

PROJECT SUMMARY: Both neuropathic pain and epilepsy are common chronic disorders which result in significant morbidity to the sufferer, and have a major impact on health resources. Severe chronic pain...

...– for example, if you are getting a brain scan for an unrelated condition. Some of the tests that can detect an aneurysm include: Computed tomography scan (CT or CAT...

...diagnosis may take some time. Diagnosis can be assisted through a range of tests, some which eliminate other conditions eg; nerve conduction tests. The causes of MND are not yet...

...the neuroinflammation will limit the damage the brain suffers after TBI. In our laboratory we have been researching the effect of the interferon signaling system and neural injury. Interferon is...

...genetic cause of DYT4 in affected family members. We will test the effect of these genetic mutations in a number of tissues sampled (under local anaesthetic) from affected and unaffected...

...aims to evaluate the role of FoxM1 in the growth of melanoma cancer cells in a test tube environment. The overall goal is to characterise the expression of FoxM1 in...

PROJECT SUMMARY: Glioblastoma multiforme (GBM) is the most common malignant brain tumour and has a very poor survival (7-15 months) despite current best treatment (surgery, chemotherapy and irradiation). Glioma stem...

...or whether instead it remains effective when targeted at remote tissues. Specifically, we will test the novel idea that NIr-induced neuroprotection is mediated by stem cells that are released from...

PROJECT SUMMARY: Medulloblastoma is a malignant brain tumour that is the most common cause of cancer-related death in children. Recent studies have described at least four distinct subgroups of medulloblastoma...

...may provides a novel complementary strategy for treating GBM. In this proposal, we will test the hypothesis that activating NFI in primary GBM tumours both stops their growth and reverses...

...reverse the primary damage and complex secondary pathologies that develop following a TBI. It is crucial that we understand the mechanisms by which the brain responds to injury before we...

...neuron disease. Advancing earlier studies that have explored the basis for neurological symptoms in sporadic motor neuron disease. This may result in the development of a sensitive diagnostic test for...

...in a special way- differs from cancer and heart disease in a very baffling way- there is no pathology. You can’t perform a brain scan or a blood test to...

...these mice to test the efficacy of compounds we have under development as potential therapeutics for neurodegenerative disease. The testing we have already completed indicates our compounds have good therapeutic...

...examining a single episodic memory task in 1999 showed an association between memory and lipid levels. Examining lipid measures from 1991-1999, showed that serum concentration measures closer to the time...

...acute damage to their surface membrane, and is the first identified component of membrane repair machinery. We have been studying the biology of dysferlin in muscle cells; where it goes,...

...study forms part of a cluster of projects examining genetic influences on acquired epilepsies. These projects will test the hypothesis that variations in the immune/inflammatory response determine whether or not...

...optica as a separate entity and the role of the aquaporin-4 antibody plays in diagnosis. Through a combination of extensive population-based collection of clinical data and systematic testing with MRI...

...cardiovascular disease. But migraine differs from cancer and heart disease in a very baffling way- there is no pathology. We can’t perform a brain scan or a blood test to...

...is to develop a novel animal model, in which upper motor neurones are positively identified due to their selective expression of a fluorescent protein marker, and then to test the...

...rehabilitation. Vestibular Schwannomas also provide an excellent disease model for studying selective vestibulopathy affecting the superior and inferior vestibular nerves. Our work will help validate a quantitative and lateralizing test...
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