Archive

Project Summary: In syringomyelia, fluid cysts expand and damage the spinal cord and can lead to disabling pain, paralysis and other neurological effects. Treatment is often unsuccessful because the exact mechanisms of how fluid circulates in the spine and builds up in the spinal cord is...

Project Summary: Multiple  system  atrophy  (MSA)  affects  over  2000  Australians.  MSA  is  a  distinct  member  of   the  group  of  neurodegenerative  diseases  called  α-­synucleinopathies  whereby  the  fibrillar   protein  α-­synuclein  aggregates  in  brain  tissue.  Although  well-­defined  clinically  the  molecular   causes  of  MSA  has  not  yet  been  elucidated.   ...

Project Summary: Tremor is the rhythmic shaking of a body part and is a common and disabling problem seen in diseases such as Parkinson’s disease and Essential Tremor. At present there is no single diagnostic test to determine the cause of a person’s tremor. This represents...

Project Summary: Thyroid hormone is essential for regulation of cell metabolism. Hyperthyroidism is an elevation of thyroid hormone levels. It is a common condition affecting up to 1.3% of the population. Muscle weakness involving the shoulders and hips is a well-recognised complication and affects 60-80% of...

Project Summary: Chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are immune disorders of the peripheral nerves. Both conditions can cause significant weakness and functional disability including difficulty with walking and ability to carry out self-care. CIDP and MMN are extremely heterogenous with varied...

Project Summary: Tourette syndrome/tics, obsessive compulsive disorder and autism are very common neuropsychiatric diseases with onset in childhood affecting 1 in 50-200 people. Tourette syndrome is characterized by multiple motor tics and vocal tics. Obsessive-compulsive disorder (OCD) in children causes unwanted thoughts resulting in repetitive compulsive...

Project Summary: Motor neurone disease (MND) is a universally fatal neurodegenerative disease with no known cure. More than 2000 people in Australia are affected by motor neurone disease with an average life expectancy of 2.5 years. Classical amyotrophic lateral sclerosis (ALS) accounts for some 80% of MND...

Project Summary: Inclusion Body Myositis (IBM) is the most common type of inflammatory muscle disease that affects adults over 40 years old. IBM leads to progressive wasting and weakness of muscles, particularly the thighs and forearms. Because of non-specific initial symptoms, which include difficulty in climbing...

Project Summary: Stroke is an important cause of epileptic seizures in adults. While several factors associated with the development of epilepsy after stroke have been identified, predicting which patients will develop seizures remains difficult. One of the most important biological factors that may be relevant is...

Project Summary: Stroke is the most frequent cause of permanent disability in adults and a major cause of death worldwide. Caused by a sudden blockage in important blood vessels that supplies oxygen and nutrients to the brain, brain cells can quickly die due to starvation. Opening...

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