Archive

PROJECT SUMMARY: Dementia and diabetes are two of the most common and disabling conditions worldwide, responsible for an enormous and growing burden of disease. There is increasing awareness that the two conditions are linked, with cognitive impairment (worsening memory, thinking and perception) common in people with...

PROJECT SUMMARY: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressing neurodegenerative disease whereby 50% of cases die within 3 years. Diagnosis involves a clinical examination with a questionnaire-based scale (ALSFRS-R) and a nerve conduction test. The process from symptom presentation to diagnosis can take an average...

PROJECT SUMMARY: Parkinson’s disease (PD) is a significant global problem, affecting 10 million people worldwide. In Australia alone, 1 in every 350 Australians suffer from PD, with 32 new cases diagnosed each day. PD is associated with significant burden to the Australian economy, with total financial...

PROJECT SUMMARY: Brain arteriovenous malformations (AVMs) are abnormalities of blood vessels, in which direct connections form between arteries and veins. This leads to a high risk of rupture causing stroke which carries a 50% risk of death or disability in the children and young adults typically...

PROJECT SUMMARY: Human brain tumours (gliomas) generally afflict young individuals in their 30s-40s with significant implications for the individual, their family, as well as a large burden of disease for the community. Currently there are no cures for high grade gliomas and the conventional therapy on...

PROJECT SUMMARY: Epilepsy affects more than 250,000 Australians, with many of these being refractory to conventional therapies.  This is a very costly condition to treat and it causes significant psychosocial burden.  Our current research into a unique epilepsy subgroup which are refractory to conventional therapies is...

PROJECT SUMMARY: The Development and Management of Post traumatic Epilepsy Post traumatic epilepsy (PTE) is a significant health burden on patients who suffer traumatic brain injury (TBI), which is observable and may be preventable. PTE is often treatment resistant, and associated with significant morbidity and mortality. Investigation...

PROJECT SUMMARY: In addition to the motor consequences of epilepsy, seizures result in cardiovascular and respiratory consequences that, in some individuals may lead to death. Indeed, Sudden Unexplained Death in Epilepsy (SUDEP) is one of the most poorly understood consequences of epilepsy. By definition, the mechanisms...

PROJECT SUMMARY: Amyloid and paraprotein-associated neuropathies (APAN) are a neglected group of debilitating peripheral nerve disorders, resulting in weakness, sensory disturbance, pain and functional impairment for patients, including difficulty walking and performing activities of daily living. APAN are frequently misdiagnosed, leading to delays in correct diagnosis,...

PROJECT SUMMARY: Establishing an Australian pediatric peripheral neuropathy biobank : a rich future scientific research resource. Peripheral nerve diseases result in progressive muscle weakness and wasting, and many with childhood onset may lead to significant disability and reduced survival. Spinal muscular atrophy (SMA) is a noteworthy exemplar,...

PROJECT SUMMARY: Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease affecting the brain and spinal cord. There are over 25,000 Australians living with MS and it is one of the most common causes of neurological (brain and spinal cord) disability in young adults. In MS clinical...

PROJECT SUMMARY: STOP-BANG and upper airway sensation testing to increase the predictive value of obstructive sleep apnoea in people with multiple sclerosis. Fatigue is a chronic and debilitating feature of multiple sclerosis (MS) which is not fully understood. It is multifactorial and often reduces quality of life...

PROJECT SUMMARY: Medulloblastoma (MB) is the most common fatal childhood brain cancer. Despite significant advances in the treatment of low-risk MB patients, children with high-risk MB have low survival rates and there are currently very few treatment options available including surgery, radiotherapy and chemotherapy. Due to...

PROJECT SUMMARY: When trauma or disease damages the connection between the motor nerves and skeletal muscle, muscle wasting occurs. This leads to impaired mobility, lack of independence and may even lead to death. Some of the peripheral nerves are able to repair and recover functional connections...

PROJECT SUMMARY: Effect of respiration and pathways of fluid flow in spinal cord cysts Traumatic spinal cord injury is a devastating condition affecting approximately 600 people each year in Australia and 13,000 in the USA. Of these, up to one third will develop syringomyelia. This condition is...

PROJECT SUMMARY: Childhood concussion is on the rise. Over 1 in 10 children who present to an emergency care setting with a mild traumatic brain injury (mTBI) will develop persistent concussion symptoms 4 weeks after their injury. The impact of this injury is concerning as it...

PROJECT SUMMARY: Traumatic brain injury (TBI) is a leading cause of disability in Australia and worldwide. The effects of TBI are profound and often long term.  Adverse outcomes are wide ranging and can include confusion, memory loss, depression, cognitive decline, epilepsy and eventual development of dementia....

PROJECT SUMMARY: Approximately 200-300 individuals sustain a traumatic spinal cord injury (SCI) each year within Australia, however globally this number is far greater with 250,000 to 500,000 SCIs occurring worldwide. Fortunately, due to improvements in clinical care, survival rates following SCI are very high. While this...

PROJECT SUMMARY: Nerve excitability in sporadic migraine and monogenic familial hemiplegic migraine. Migraine is very common, affecting almost 1 in 3 women and about 1 in 8 men and costs Australians about $36bn dollars a year. For many of the more severely affected, it is a constant...

Brain FoundationThe Brain Foundation is the largest, independent funder of brain and spinal injury research in Australia. We believe research is the pathway to recovery.
PLEASE HELP US BY DONATING TO OUR RESEARCH PROGRAM.