Archive

PROJECT SUMMARY: Dementia and diabetes are two of the most common and disabling conditions worldwide, responsible for an enormous and growing burden of disease. There is increasing awareness that the two conditions are linked, with cognitive impairment (worsening memory, thinking and perception) common in people with...

PROJECT SUMMARY: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressing neurodegenerative disease whereby 50% of cases die within 3 years. Diagnosis involves a clinical examination with a questionnaire-based scale (ALSFRS-R) and a nerve conduction test. The process from symptom presentation to diagnosis can take an average...

PROJECT SUMMARY: Parkinson’s disease (PD) is a significant global problem, affecting 10 million people worldwide. In Australia alone, 1 in every 350 Australians suffer from PD, with 32 new cases diagnosed each day. PD is associated with significant burden to the Australian economy, with total financial...

PROJECT SUMMARY: Brain arteriovenous malformations (AVMs) are abnormalities of blood vessels, in which direct connections form between arteries and veins. This leads to a high risk of rupture causing stroke which carries a 50% risk of death or disability in the children and young adults typically...

PROJECT SUMMARY: Human brain tumours (gliomas) generally afflict young individuals in their 30s-40s with significant implications for the individual, their family, as well as a large burden of disease for the community. Currently there are no cures for high grade gliomas and the conventional therapy on...

PROJECT SUMMARY: Epilepsy affects more than 250,000 Australians, with many of these being refractory to conventional therapies.  This is a very costly condition to treat and it causes significant psychosocial burden.  Our current research into a unique epilepsy subgroup which are refractory to conventional therapies is...

PROJECT SUMMARY: The Development and Management of Post traumatic Epilepsy Post traumatic epilepsy (PTE) is a significant health burden on patients who suffer traumatic brain injury (TBI), which is observable and may be preventable. PTE is often treatment resistant, and associated with significant morbidity and mortality. Investigation...

PROJECT SUMMARY: In addition to the motor consequences of epilepsy, seizures result in cardiovascular and respiratory consequences that, in some individuals may lead to death. Indeed, Sudden Unexplained Death in Epilepsy (SUDEP) is one of the most poorly understood consequences of epilepsy. By definition, the mechanisms...

PROJECT SUMMARY: Amyloid and paraprotein-associated neuropathies (APAN) are a neglected group of debilitating peripheral nerve disorders, resulting in weakness, sensory disturbance, pain and functional impairment for patients, including difficulty walking and performing activities of daily living. APAN are frequently misdiagnosed, leading to delays in correct diagnosis,...

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