“The hope is that by understanding the basic mechanisms of epileptogenesis in more detail, we can identify targets for treatment, in particular cellular targets that can be treated.”
Watch the full interview with Dr Alexander Bryson below.
Project Summary:
Epilepsy is a common condition characterised by seizures: bursts of abnormal brain activity. While current treatments help many people, many patients continue to experience seizures that greatly impact their lives. Although research has uncovered many of the genetic causes of epilepsy, we still lack a clear understanding of what happens to the brain as epilepsy develops over time, which limits the development of better therapies.
This project will use advanced optical imaging technology to track brain activity in a mouse model of epilepsy. Using a technique called two-photon calcium imaging, the team can observe thousands of neurons in action by detecting tiny flashes of light when they fire. This allows researchers to follow neural activity as the brain develops epilepsy and produces seizures. The chosen mouse model carries a mutation that closely mirrors how epilepsy arises in humans, giving valuable insights into the disease process.
Overall, this study will reveal changes to brain activity associated with epilepsy that lie beyond the resolution of standard neuroimaging techniques. This will uncover critical points where interventions could prevent epilepsy from developing or reduce its severity. With the imaging tools and models already established, this project is well-positioned to deliver discoveries that could pave the way for more effective and targeted treatments, improving the outlook for people with epilepsy.
The Brain Foundation is dedicated to funding the next generation of Australian research into brain disorders, diseases, and injuries, with the ultimate goal of advancing diagnoses, treatments, and patient outcomes.