In this project we hope to discover the cause of migraine headache. Many “triggers” lead to migraine, but we do not know how. We believe the triggers produce a defect in pain control by the brainstem, which normally keeps sensation from the head below the pain threshold. In migraine, trigger factors originating in the cortex open this “pain control gate”, producing a migraine headache. If we can prove this, we can develop therapies that will prevent migraine before it starts.