A new hypothesis of Motoneuron Disease: astrocytes are the non-neuronal neighbours inducing motoneuron injury
Professor Philip M Beart
Brain Injury & Repair, Howard Florey Institute and University of Melbourne
Funded By Michael Rogers Stirling Estate
Co-Investigators : Dr Julie Atkin and Dr Ross O’Shea
Project Summary:
Motor Neurone Disease is a neurodegenerative condition, progressing to paralysis in 1-5 years, and killing 100,000 every year world-wide. We seek to understand its pathogenesis by investigating the underlying mechanisms, which involve different neighbouring cells contributing to the injury of motoneurons. Ongoing work from our laboratory reveals that a population of glial cells, astrocytes, which are intimately associated with motoneurons, profoundly affect their function and existence. We believe that changes to the chemistry and shape of astrocytes initiate a neurotoxic milieu, and that dissection of their roles will provide new clues for management of Motor Neurone Disease.
The Brain Foundation is dedicated to funding the next generation of Australian research into brain disorders, diseases, and injuries, with the ultimate goal of advancing diagnoses, treatments, and patient outcomes.