Disorders

Parkinson’s Disease Award - 2015

Dr Wesley Thevathasan was the recipient of BF grant funding in 2015

Parkinson’s Disease Award

Parkinson’s Disease Award
Improving walking disorders in Parkinson's patients using cueing
Dr Wesley Thevathasan
Royal Melbourne Hospital
Co-Investigators : Dr Thushara Perera, Professor Hugh McDermott, Dr Jennifer McGinley, Miss Joy Tan, Mr Shivanthan Yohanandan
Shivy Yohandan on behalf of Thevathasan (1) Shivy Yohandan on behalf of Dr Thevathasan

PROJECT SUMMARY:

Freezing of gait is a debilitating symptom of Parkinson’s disease associated with a heightened falls risk, which is a prevalent cause for morbidity and mortality. Individuals describe it as the feeling that their feet are glued to the ground leaving them frozen and unable to move when trying to walk. These freezing episodes can last from a few seconds to several minutes. Freezing is usually associated with reduced walking (gait) speed and step length. It occurs during gait initiation, turning or when encountering obstacles.

An estimated 10 million people worldwide are living with Parkinson’s disease, and the prevalence of gait freezing is up to 60% of this population. It is an incapacitating motor symptom, as it significantly affects patients’ quality of life and levels of activity. Total loss of movement can also leave patients wheelchair-bound. Furthermore, psychological conditions such as depression and anxiety are common in patients with freezing.

Gait freezing is a progressive condition, and at its onset is usually treatable with oral medications. As the disease worsens, more invasive therapies such as deep brain stimulation (DBS) are required. However, DBS does not improve freezing in many patients and therefore a novel intervention is required to treat this disabling symptom. Recent studies which utilised auditory, visual or vibratory cues to unfreeze patients have shown promise.

In our study we propose a feedback system consisting of instrumented shoe-insoles that can detect and unfreeze gait freezing using either vibration, visual or auditory cueing. So far we have designed, manufacturered and validated the insoles in a clinical study. We now plan to compare auditory, visual and vibratory cues to determine which one provides greatest efficacy. This knowledge will then be incorporated into our instrumented insoles to provide adaptive cues during walking to ensure patients do not freeze.

Progress Report

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