Alzheimer’s and Other Neuro Degenerative Diseases - 2019

Dr Li-Ann Leow was the recipient of Brain Foundation grant funding in 2019

Alzheimer’s and Other Neuro Degenerative Diseases

Alzheimer’s and Other Neuro Degenerative Diseases
The role of dopamine in age-related deficits in sensorimotor adaptation
Dr Li-Ann Leow
University of Queensland, QLD
Co-Investigators : Professor Timothy Carroll, Dr Eva-Maria Reuter, Professor Penny Macdonald, Dr Rob Adam, Professor Stephan Riek

Project Summary:

We all hope to live independently, for as long as possible. This functional independence requires a form of motor learning called sensorimotor adaptation, which is the capacity to adapt movement to change. For example, problems adapting to changes in the body (e.g., arthritis) or in the environment (e.g., walking onto a slippery floor, manoeuvring obstacles, etc) increases risk of falls. Falls are common and costly: in Australia, a third of community-dwelling older adults (>65 years old) fall at least once a year, with many falls resulting in hospitalization (>100,000 hospitalizations in 2014–15). Unfortunately, sensorimotor adaptation is impaired in older adulthood), even pre-retirement. Why does ageing impair sensorimotor adaptation?

One likely culprit is the profound degeneration of our dopaminergic system. In older adulthood, we lose up to 50% of our dopamine neurons in the substantia nigra/ventral tegmental area. Every decade after age 20, we lose 5-10% of our dopamine receptors and transporters. This project directly tests the idea that deficient dopamine neurotransmission with ageing impairs multiple components of sensorimotor adaptation. Our approach is two-pronged. First, we pharmacologically manipulate dopamine in older adults. Second, we leverage state-of-the-art methods of experimentally dissociating the multiple components of adaptation. Our approach will elucidate the role of dopamine in sensorimotor adaptation, a crucial step towards forming a comprehensive framework of the neural mechanisms that underpin age-related declines in sensorimotor adaptation. More importantly, our work will test the feasibility of remediating age-related decline of sensorimotor adaptation through pharmacological means. Increasing evidence from animal and human clinical studies suggest that dopamine pharmacotherapy can improve outcomes in movement rehabilitation, however, how dopamine pharmacotherapy improves rehabilitation is unknown. This work will fill this knowledge gap by testing how dopamine pharmacotherapy affects the multiple components of sensorimotor adaptation, which forms the basis of many forms of movement rehabilitation.

Click to read Progress Report (Oct 2020)

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